The first-return time is the time that it takes a random walker to go back to the initial position for the first time. In this paper, the first-return time is studied when random walkers perform fractional kinetics, specifically fractional diffusion, that is modelled within the framework of the continuous-time random walk on homogeneous space in the uncoupled formulation with Mittag-Leffler distributed waiting-times. Both the Markovian and non-Markovian settings are considered, as well as any kind of symmetric jump-size distributions, namely with finite or infinite variance. It is shown that the first-return time density is indeed independent of the jump-size distribution when it is symmetric, and therefore it is affected only by the waiting-time distribution that embodies the memory of the process. The analysis is performed in two cases: first jump then wait and first wait then jump, and several exact results are provided, including the relation between results in the Markovian and non-Markovian settings and the difference between the two cases.